According to some embodiments, a thermal conditioning system for selectively cooling skin of a subject comprises at least one thermal conditioning device comprising a first side and second side, the second side being generally opposite of the first side. In some embodiments, the system further comprises a heat sink positioned along the second side of the at least one thermal conditioning device, wherein the first side of the at least one thermal conditioning device is configured to be placed in contact with or in close proximity to a skin surface of the subject to selectively cool or heat the skin surface.
