The invention provides a promoter for generation of glutathione obtaining ingredients from natural objects with high safety, and provides pharmaceuticals, foodstuff, or cosmetics comprising the promoter for generation of glutathione and with glutathione generation promoting effect. The promoter for generation of glutathione comprises a plant extract comprising Saussurea species, in particular an extract selecting from more than one plant of Saussurea involucrata (Kar.et Kir.) Sch.Blp.), Saussurea medusa Maxim.) and Saussurea laniceps Hand.-Mazz. as active ingredients.