Christian Frisch,Achim Knappik,Alex Y. Strongin,Sergey A. Shiryaev
申请号：
US13379680
公开号：
US09133500B2
申请日:
2010.08.06
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention discloses novel screening strategies for the identification of binders that target the active site of enzymatic antigens. The present invention also discloses antigen-binding moieties which bind to the NS2B-NS3 Proteinase of West Nile Virus, in particular binders which bind to the active site, thereby inhibiting the enzymatic activity of the proteinase. The antigen-binding moieties of the present invention have numerous therapeutic and diagnostic applications.
