PEPTIDES MAML VARIANTS STABILISÉS ET LEURS UTILISATIONS

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专利权人:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人:

MOELLERING, RAYMOND EARLE,VERDINE, GREGORY, L.

申请号：

EP12800679

公开号：

EP2721061A4

申请日:

2012.06.15

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

Internally cross-linked peptides derived from human MAML and derivatives thereof which exhibit affinity for the ICN1-CSL complex are described and characterized. The peptides can interfere with NOTCH signaling and are thus useful for treating various disorders, including certain cancers.

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