Disclosed herein, in certain embodiments, is a method of inhibiting or treating a cancer with use of a TNF expressing myxoma virus. Also disclosed herein are methods of inhibiting or treating a cancer with use of a mononuclear peripheral blood cells and/or a bone marrow cells treated with a TNF-expressing myxoma virus. Some aspects relate to engineered myxoma virus and pharmaceutical compositions for use with one or more of the methods described herein.在某些實施例中，本文揭示一種使用表現TNF之黏液瘤病毒抑制或治療癌症之方法。本文亦揭示使用以表現TNF之黏液瘤病毒處理之單核末梢血液細胞及/或骨髓細胞抑制或治療癌症之方法。一些態樣係關於與一或多種本文所描述之方法一起使用的經改造之黏液瘤病毒及醫藥組合物。
