The Rockefeller University;BRISTOL-MYERS SQUIBB COMPANY
发明人:
Jeffrey V. Ravetch,Rony Dahan,Bryan C. Barnhart,Brigitte Devaux,Aaron P. Yamniuk,Shannon L. Okada,Brenda L. Stevens
申请号：
US15195098
公开号：
US10479838B2
申请日:
2016.06.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
