Suzanne Ostrand-Rosenberg;Jacobus J. Bosch;Bruce R. Ksander
发明人:
Suzanne Ostrand-Rosenberg,Jacobus J. Bosch,Bruce R. Ksander
申请号：
US12889043
公开号：
US08444965B2
申请日:
2010.09.23
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified to express MHC-II restricted peptides derived from endogenously encoded tumor antigens, activate CD4+ T-lymphocytes, provide an array of antigens to which the host is not tolerized and/or induce immunity against the originating tumor cells as well as against metastatic tumor cells.
