Thiresen Govender,Viness Pillay,Yahya Essop Choonara,Lisa Claire Du Toit,Girish Modi,Dinesh Naidoo,Maluta Steven Mufamadi
申请号：
US13989402
公开号：
US20130344125A1
申请日:
2011.11.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides an implantable intracranial device for the site-specific delivery of a pharmaceutically active agent to a human or animal for treating a mental or neurological disorder, such as Alzheimers disease, schizophrenia or other psychoses. The biodegradable device includes a pharmaceutically active agent for treating the disorder, polymeric nano-lipoparticles into or onto which the pharmaceutically active agent is embedded and a polymeric matrix or scaffold incorporating the nano-lipoparticles. The nano-lipoparticles can be in the form of nano-liposhells or nano-lipobubbles. The nano-liposhells or nano-lipobubbles can include an essential fatty acid or can be conjugated to a peptide ligand which targets the device to a specific cell into which the therapeutic agent can be delivered. The device can be implanted in the sub-arachnoid space in the region of the frontal lobe of the brain.
