GOVENDER THIRESEN,PILLAY VINESS,CHOONARA YAHYA ESSOP,DU TOIT LISA CLAIRE,MODI GIRISH,NAIDOO DINESH,MUFAMADI MALUTA STEVEN
申请号：
IN5753/DELNP/2013
公开号：
IN2013DN05753A
申请日:
2013.06.26
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The invention provides an implantable intracranial device for the site specific delivery of a pharmaceutically active agent to a human or animal for treating a mental or neurological disorder such as Alzheimer s disease schizophrenia or other psychoses. The biodegradable device includes a pharmaceutically active agent for treating the disorder polymeric nano lipoparticles into or onto which the pharmaceutically active agent is embedded and a polymeric matrix or scaffold incorporating the nano lipoparticles. The nano lipoparticles can be in the form of nano liposhells or nano lipobubbles. The nano liposhells or nano lipobubbles can include an essential fatty acid or can be conjugated to a peptide ligand which targets the device to a specific cell into which the therapeutic agent can be delivered. The device can be implanted in the sub arachnoid space in the region of the frontal lobe of the brain.
