YOON, JAE BONG,윤재봉,YOO, JIN SANG,유진상,YOO, JIN SAN,유진산,LEE, WEON SUP,이원섭,KIM, SUNG WOO,김성우,SHIM, SANG RYEOL,심상렬,BYUN, SANG SOON,변상순,LEE, YOUNG AE,이영애,LEE, HYUK JOON,이혁준,KIM, DO YUN,김도윤,CHOI, JIN HEE,최진,YOON, JAE BONGKR,YOO, JIN SANGKR,YOO, JIN SANKR,LEE, WEON SUPKR,KIM, SUNG WOOKR,SHIM, SANG RYEOLKR,BYUN, SANG SOONKR,LEE, YOUNG AEKR,LEE, HYUK JOONKR,KIM, DO YUNKR
申请号：
KR1020140165417
公开号：
KR1020160062535A
申请日:
2014.11.25
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to an antibody specifically binding to epidermal growth factor receptor variant III (EGFRvIII), to nucleic acid coding the antibody, to a vector comprising the nucleic acid, to a host cell, to a preparation method of the antibody, and to a pharmaceutical composition comprising the antibody as an effective component for treating cancer or tumor. The antibody of the present invention specifically binds to the region of first to thirteenth amino acid among the amino acid sequence of EGFRvIII represented by SEQ ID NO: 1, without being cross-reactive to wild-type EGFR.본 발명은 EGFRvIII (epidermal growth factor receptor variant III)에 특이적으로 결합하는 항체, 상기 항체를 코딩하는 핵산, 상기 핵산을 포함하는 벡터, 숙주세포, 상기 항체의 제조방법 및 상기 항체를 유효성분으로 포함하는 암 또는 종양 치료용 약학 조성물에 관한 것이다.
