MOHAMMED AQIL,ABDUL AHAD,KANCHAN KOHLI,YASMIN SULTANA,MOHD MUJEEB,ASGAR ALI
申请号：
IN1998/DEL/2010
公开号：
IN2010DE01998A
申请日:
2010.08.24
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
This invention relates to a novel formulation to transdermally/transmucosally deliver a pharmaceutically active principle at a therapeutically effective rate by a skin permeation enhancing factor comprising a a-terpinene 1-5% w/v, a covalent ethanol 0-40% v/v in the main solvent isotonic phosphate buffer (pH 7.4) and the method of preparation thereof comprising the steps of, Preparing a sub saturated or saturated drug solution in the vehicle, i.e. ethanol: IPB (pH 7.4) (40:60) mixture, Adding a- terpinene to the donor phase in increasing concentration ie 1%, 3% and 5%.
