PROBLEM TO BE SOLVED: To provide a silica-based particle which has a spherical particle shape, substantially no cavity inside of the particle and porous or nonporous inside, or a silica-based particle which has a porous or nonporous outer shell, a cavity inside of the outer shell, further a manufacturing method of the silica-based particle which has the nonporous outer shell and the cavity inside of the outer shell and negative pressure inside, a cosmetic, a resin composition and a heat insulation material blending the same.SOLUTION: There is provided a manufacturing method including following processes (a) to (c). (a) a process of preparing a silica-based particle precursor particle by spraying and drying a silicate alkali solution into a hot air flow. (b) a process of immersing the silica-based particle precursor particle into an acid solution to remove alkali. (c) a process of drying and heat treatment.COPYRIGHT: (C)2015,JPO&INPIT【課題】粒子形状が球状であり、粒子内部に実質的に空洞がなく、内部が多孔質または非孔質(無孔質)であるシリカ系粒子、あるいは外殻を有し、外殻内部に空洞を有し、外殻が多孔質または非孔質であるシリカ系粒子、さらに、外殻を有し、外殻内部に空洞を有し、外殻が非孔質であり、内部が負圧であるシリカ系粒子の製造方法、該シリカ系微粒子及びこれを配合した化粧料、樹脂組成物、断熱材の提供。【解決手段】下記工程(a)~(c)からなる製造方法。(a)珪酸アルカリ水溶液を熱風気流中に噴霧乾燥してシリカ系粒子前駆体粒子を調製する工程、(b)シリカ系粒子前駆体粒子を酸水溶液に浸漬し、アルカリを除去する工程、(c)乾燥・加熱処理する工程【選択図】なし