The invention claims protection for an arctigenin sublingual preparation and a use of the arctigenin sublingual preparation in the preparation of a medicine for treating a disease, and belongs to the field of medicines. According to the arctigenin sublingual preparation provided by the invention, a biological viscous material and an absorption promoter are added to effectively improve the absorption characteristic of the arctigenin sublingual preparation. When the arctigenin sublingual preparation provided by the invention is applied to treating a tumor, the tumor inhibition ratio of the medicine can be obviously improved, and the survival rate of a patient can be improved. The arctigenin sublingual preparation provided by the invention is high in biological availability, the treatment compliance of the patient can be improved, and therefore the arctigenin sublingual preparation has a good medical application prospect.
