An immunogenic molecular entity comprising at least one hapten linked to a macromolecular vehicle, wherein the hapten comprises a cyclic peptide comprising a macrocyclic ring, wherein the cyclic peptide comprises the amino acid sequence selected from the group consisting of RIPT (Xa + 2 ) TGFF (SEQ ID NO: 110), GVNP (Xa + 2) GGWF (SEQ ID NO: 96), KAKT (Xa + 2) TVLY (SEQ ID NO: 97), KTKT (Xa + 2) TVLY (SEQ ID NO: 98), GANP (Xa + 2) OLYY (SEQ ID NO: 99), GANP (Xa + 2) ALYY (SEQ ID NO: 100), GYST (Xa + 2) SYYF (SEQ ID NO: 101), GYRT (Xa + 2) NTYF (SEQ ID NO: 102), YNP (Xa + 2) VGYF (SEQ ID NO: 103), GGKV (Xa + 2) SAYF (SEQ ID NO: 104), SVKP (Xa + 2 ) TGFA (SEQ ID NO: 105), DSV (Xa + 2) ASYF (SEQ ID NO: 106), KYNP (Xa + 2) SNYL (SEQ ID NO: 107), KYNP (Xa + 2) ASYL (SEQ ID NO: 108), KYNP (Xa + 2) ANYL (SEQ ID NO: 109), DI (Xa + 2) NAYF (SEQ ID NO: 111), DM (Xa + 2) NGYF (SEQ ID NO: 112), KYNP (Xa + 2) LGFL (SEQ ID NO: 113), KYYP (Xa + 2) FGYF (SEQ ID NO: 114), GARP (Xa + 2) GGFF (SEQ ID NO: 115), GAKP (Xa + 2 ) GGFF (SEQ ID NO: 116), YSP (Xa + 2) TNFF (SEQ ID NO: 117), YSP (Xa + 2) TNF (SEQ ID NO: 118), QN (Xa + 2) PNIFGQWM (SEQ ID NO: 119), where the last amino acid residue of each sequence is X1 , which is an amino acid residue that is covalently linked to an R group through the respective carbonyl group； Xa + 2 is any amino acid, of which the respective carbon atom is covalently bound to R； where R comprises -CH2O-, -CH2CH2O-, -CH2CH (CH3) O-, -CH2-phenyl-O-, -CH2S, -CH2CH2S- or - (CH2) nNH-, where n ranges from 1 to approximately 4； and wherein the N-terminal amino acid residue of the cyclic peptide is attached to the macromolecular vehicle； and wherein the macromolecular vehicle is of sufficient size, in conjunction with the hapten attached thereto, to activate the appearance of an immune response by an organism exposed to the immunogenic molecular entity.Una entidad molecular inmunogénica que comprende al menos un hapteno ligado a un vehículo macromolecular, en don
