PROBLEM TO BE SOLVED: To provide new protease resistant polypeptides, as well as compositions and methods, for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.SOLUTION: The present invention provides an isolated polypeptide containing a specific amino acid sequence, having cartilage formation activity.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2020,JPO&INPIT【課題】急性の関節傷害および関節炎を含む関節損傷と関連する状態を治療、改善または予防する新規のプロテアーゼ抵抗性ポリペプチドならびに組成物および方法の提供。【解決手段】軟骨形成活性がある、特定のアミノ酸配列を含む単離ポリペプチド。【選択図】図1