Nowe polimorficzne formy soli chlorowodorku 3-(1-{3-[5-(1-metylo-piperydyno-4-ylometoksy)-pirymidyno-2-ylo]-benzylo}-6-okso-1,6-dihydro-pirydazyno-3-ylo)-benzonitrylowego oraz sposoby ich otrzymywania
BECKER, AXEL,KUEHN, CLEMENS,SAAL, CHRISTOPH,SCHADT, OLIVER,DORSCH, DIETER,BOKEL, HEINZ-HERMANN,STIEBER, FRANK,DONINI, CHRISTINA
申请号：
PL09764204
公开号：
PL2373640T3
申请日:
2009.12.04
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
Compounds of the present invention concern 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The compound, 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile, has the following structural formula: The hydrochloride solvates and crystalline modifications thereof according to the invention are useful for treatment of physiological and/or pathophysiological conditions, such as cancer, that are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, especially Met-kinase. The present invention further relates to processes of manufacturing these crystalline modifications.
