"Polymorphic forms of 3- (1- {3- [5- (1-methyl-piperidin-4-ylmethoxy) -pyridin-2-yl] -benzyl} -6-oxo-1,6-dihydrochloride hydrochloride salt"). hydro-pyridazin-3-yl) benzonitrile and processes for the manufacture thereof "
AXEL BECKER,CHRITOPH SAAL,CLEMENS KUEHN,CRISTINA DOMINI,DIETIER DORSCH,FRANK STIEBER,HEINZ-HERMANN BOCKEL,OLIVER SCHADT
申请号：
BRPI0922642
公开号：
BRPI0922642A2
申请日:
2009.12.04
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
Compounds of the present invention concern 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The compound, 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile, has the following structural formula: The hydrochloride solvates and crystalline modifications thereof according to the invention are useful for treatment of physiological and/or pathophysiological conditions, such as cancer, that are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, especially Met-kinase. The present invention further relates to processes of manufacturing these crystalline modifications.
