NOVEL POLYMORPHIC FORMS OF 3-(1--(3-[5-(1-METHYL-PIPERIDIN-4-YLMETHOXY)-PYRIMIDIN-2-YL]-BENZYL}-6-OXO-1, 6-DIHYDRO-PYRIDAZIN-3-YL)-BENZONITRILE HYDROCHLORIDE SALT AND PROCESSES OF MANUFACTURING THEREOF
BECKER AXEL,KUEHN CLEMENS,SAAL CHRISTOPH,SCHADT OLIVER,DORSCH DIETER,BOKEL HEINZ HERMANN,STIEBER FRANK,DONINI CHRISTINA
申请号：
IN3345/KOLNP/2011
公开号：
IN2011KN03345A
申请日:
2011.08.08
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention relates to hydrochloride solvates of 3-(1-{3-[5-(1-methyl- piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3- yl)-benzonitrile and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/ or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
