The present invention is directed to Buprenorphine Analog compounds of the Formula I, Formula II, Formula III, Formula IV, and Formula V, wherein R1, R2, R3a, R3b, R15a, R15b, X, Q, G, and Y are as defined herein. Compounds of the Invention are useful for treating pain and other conditions modulated by activity of opioid receptors.本發明關於式I、式Ⅱ、式Ⅲ、式Ⅳ及式V之丁基原啡因(buprenorphine)類似物化合物,其中R1、R2、R3a、R3b、R15a、R15b、X、Q、G及Y係如本文所定義者。本發明之化合物可用於治療疼痛及其他由類鴉片受體之活性調節的病症。