Novel arylpiperazine arylalkanoyl carbomoyloxy compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression when administering the compound
SK HOLDINGS CO., LTD.;SK BIOPHARMACEUTICALS CO., LTD.
发明人:
KWAK, BYONG SUNG,MOON, HONG SIK,YI, HAN-JU,KANG, YOUNG SOON,IM, DAE JOONG,CHAE, EUN HEE,CHAE, SANG MI,LEE, KI HO
申请号：
ES08753270
公开号：
ES2379848T3
申请日:
2008.04.30
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound derived from arylpiperazine arylalcanoyl carbamoyloxy having abundant enantiomeric or racemic characteristics, represented by the following Formula 1, and pharmaceutically available salts or hydrates thereof: Formula I wherein: ---- can selectively form a cyclic ring； R1 and R2 each are independently selected from the group consisting of hydrogen, straight or branched chain alkyl having 1 to 6 carbon atoms, and phenethyl, or R1 and R2 can be taken together to form a heterocyclic ring of 5 or 6 members, or R1 and R2 can be taken together with Ar1 to form a bicyclic ring； Ar1 is selected from the group consisting of furanyl, thionyl, methylenedioxyphenyl and phenyl which can be substituted by at least one identical or different substituent selected from the group consisting of hydrogen, straight or branched chain alkyl having 1 to 6 carbon atoms , halogen, straight or branched alkoxy having 1 to 6 carbon atoms, nitro and trifluoromethyl； Z is hydrogen or fluorine, or they can be taken together with Ar1 to form a bicyclic ring； Ar2 is selected from the group consisting of phenyl, methylenedioxyphenyl, pyridinyl, pyrimidinyl, naphthyl, bis (fluorophenyl) methyl and quinoxalinyl, all of which can be substituted by at least one identical or different substituent selected from the group consisting of hydrogen, alkyl straight or branched chain having 1 to 6 carbon atoms, hydroxy, halogen, straight or branched alkoxy having 1 to 6 carbon atoms, nitro, acetyl, tbutylacetyl, trifluoromethyl, amino and acetate； n is an integer of 1 or 2； and m is an integer that varies from 0 to 2.Un compuesto derivado de arilpiperazina arilalcanoil carbamoiloxi que tiene características enantioméricas o racémicas abundantes, representadas por la siguiente Fórmula 1, y sales o hidratos farmacéuticamente disponibles del mismo: Fórmula I en donde: ---- puede formar selectivamente un anillo cíclico； R1 y R2 cada uno se seleccionan independientemente del grupo que consiste de hidrógeno,
