稠合三環雜環化合物及其治療用途农业专利-农业学术服务平台

发明人:: LIU, DONG,刘　东,劉　東,CHEN, LEI,陈　磊,陳　磊,ZHUANG, LINGHANG,庄　淩航,莊　淩航,LI, PUHUI,李璞慧,ZHANG, XINZHU,张鑫竹,張鑫竹,SONG, CHUNYING,宋春英,MILLER, MATTHEW,米勒　马修,米勒　馬修,HU, QIYUE,胡　齐悦,胡　齊悅,YAN, YUNA,闫玉娜,閆玉娜,HE, FENG

摘要：: This application discloses a new class of fused tricyclic heterocycles of formula (I), preparation methods thereof, pharmaceutical compositions comprising these compounds, and pharmaceutically acceptable salts, solvates, or prodrugs thereof, and their uses for the treatment of diseases in which modulation of STING is beneficial, for example, cancers, pre-cancerous disorders, and viral infections.本申請案揭示一種新類別的式(I)之稠合三環雜環、其製備方法、包含此等化合物及其醫藥學上可接受之鹽、溶劑合物或前藥之醫藥組合物以及其用於治療其中STING之調節有益的疾病的用途，該等疾病例如癌症、癌前病症及病毒性感染。