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Compositions and radioactive methods for therapeutic use
专利权人:
Iso Therapeutics Group LLC
发明人:
WILSON, David,FRANK, R.,SIMON, Jaime,CRUMP, Druce
申请号:
ES12860525
公开号:
ES2671622T3
申请日:
2012.12.21
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A composition comprising a non-sealed, pharmaceutically acceptable, radioactive composition of the formula Qq-Tt-Aa-Bb-Cc-Rr Formula (I) wherein: Q is a substrate of a different material from the entity Aa-Bb-Cc , in which said substrate has the Aa-Bb-Cc entity deposited or adhered thereto; and is an injectable or implantable substrate that is pharmaceutically acceptable or can be coated to be pharmaceutically acceptable; q is equal to 1 or 0, where 1 means that the entity is present and 0 means that the entity is not present; T is an iron hydroxide, iron oxide, gadolinium hydroxide or non-radioactive gadolinium oxide; t is equal to 1 or 0, where 1 means that the entity is present and 0 means that the entity is not present; A is JvM * w (OH) x (CO3) and (AN) z * nH2O, where: J is a lanthanide metal ion capable of forming hydroxycarbonate compounds; v is greater than or equal to 0; M * is Sm-153, Ho-166, Y-90 or Lu-177 radioactive or mixtures thereof, in which its respective non-radioactive metal of the rare earth type is usually present; w, x and y are each independently greater than 0; AN is a pharmaceutically acceptable anionic structural unit; and z and n are each independently greater than or equal to 0; a is equal to 1 or 0, where 1 means that the entity is present and 0 means that the entity is not present; B is M * w (OH) x (CO3) and * nH2O, where: M * is radioactive Sm-153, Ho-166, Y-90 or Lu-177 or mixtures thereof, in which it is usually present their respective non-radioactive metal of the rare earth type; w, x and y are each independently greater than 0; and n is greater than or equal to 0; b is equal to 1 or 0, where 1 means that the entity is present and 0 means that the entity is not present; C is Sn (L) u- {Mw (OH) x (CO3) and * nH2O} p, where: Sn is radioactive tin (IV) -117m but also contains non-radioactive tin isotopes; L is hydrated oxide, hydroxide or oxyhydroxide such that Sn (L) u is stannic oxide, stannic hydroxide or hydrated stannic oxyhyd
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