The invention relates to medicine, namely to the cardiovascular surgery and is intended to replace diseased natural heart valves. The technical result of the utility model is to provide a biological heart valve prosthesis having a support frame, creating minimum constrictive effect and having the ability to increase the flow cross section during subsequent reimplantation into it endovascular prostheses. It proposed a biological heart valve prosthesis, consisting of an axisymmetric composite support frame comprising a rigid substrate and a wire component made of a homogeneous material, on which is mounted a flap unit, trim and sewing cuff. The rigid base support frame is a rigid three commissural strut connected cell stent with variable geometry. These racks have a triangular extension of the free end towards the narrow part of the prosthesis to the terminal area. 1 z.p.f 5 Fig.