Per Balschmidt;Thomas Børglum Kjeldsen;Inger Lautrup-Larsen;Svend Ludvigsen;Peter Kresten Nielsen;Frantisek Hubalek
发明人:
Peter Kresten Nielsen,Frantisek Hubalek,Inger Lautrup-Larsen,Per Balschmidt,Svend Ludvigsen,Thomas Børglum Kjeldsen
申请号：
US12922106
公开号：
US09260502B2
申请日:
2009.03.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to novel insulin analogs comprising mutations at position A14 in the A chain and at positions B27, B28, B29 and B30 in the B chain and exhibiting resistance towards protease； a method for the preparation of such insulin analogs； insulin preparations containing the insulin analogs of the invention； and, a method of treating diabetes mellitus using these insulin analogs.
