GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
BIGGADIKE, Keith,CHAMPIGNY, Aurelie Cecile,COE, Diane Mary,NEEDHAM, Deborah,TAPE, Daniel Terence
申请号：
PE0012692017
公开号：
PE13222017A1
申请日:
2016.01.27
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Cyclic dinucleotide referred to a compound of formula I, where R1 and R2 is NH2 Oh or NH2 R1 and R2 is h； R3 and R4 is NH2 is Oh or NH2 and H is R3, R4 is one of R5 and R6 IS F, and the other is f u Oh.It also relates to a Composition and a Pharmaceutical combination.This Compound modulates The Adapter Protein interferon Stimulating gene (Sting) and is useful in the treatment of allergic, autoimmune, inflammatory diseases, cancer, among othersReferido a un compuesto dinucleotido ciclico de formula I, donde: R1 es OH y R2 es NH2 o R1 es NH2 y R2 es H； R3 es OH y R4 es NH2 o R3 es NH2 y R4 es H； uno de R5 y R6 es F, y el otro es F u OH. Tambien se refiere a una composicion y a una combinacion farmaceutica. Dicho compuesto modula la proteina adaptadora estimuladora de genes de interferon (STING) y es util en el tratamiento de enfermedades inflamatorias, alergicas, autoinmunitarias, cancer, entre otros
