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Chemical compounds
- 专利权人:
- GLAXOSMITHKLINE LLC
- 发明人:
- AXTEN, JEFFREY MICHAEL,GRANT, SETH WILSON,HEERDING, DIRK A.,MEDINA, JESUS RAUL,ROMERIL, STUART PAUL,TANG, JUN
- 申请号：
- ES11760102
- 公开号：
- ES2530955T3
- 申请日:
- 2011.03.23
- 申请国别(地区):
- ES
- 年份:
- 2015
- 代理人:
- 摘要：
- A compound according to Formula (I): ** Formula ** in which: R1 is selected from: bicycloheteroaryl, and bicycloheteroaryl substituted with 1 to 5 substituents independently selected from: halogen, C1-6 alkyl, C1-4 alkyloxy , -OH, C1-4 hydroxyalkyl, -COOH, -CONH2, tetrazole, -CF3, -C1-4 alkyl-O (C1-4) alkyl, -CH2CH2N (H) C (O) OCH2aryl di (alkyl C1-4) amino (C1-4 alkyl) amino (C1-4) alkyl, -NO2, -NH2, -CN, aryl, aryl substituted with 1 to 3 substituents independently selected from: C1-4 alkyl, di (C1-alkyl) 4) amino (C1-4 alkyl), fluoro, chloro, bromo, iodo and -CF3, heterocycloalkyl, heterocycloalkyl substituted with one to three substituents independently selected from: C1-4 alkyl, di (C1-4 alkyl) amino (C1 alkyl -4), fluoro, chloro, bromo, iodo and -CF3, - (C1-4 alkyl) -heterocycloalkyl, - (C1-4 alkyl) -heterocycloalkyl substituted with 1 to 3 substituents independently selected from: C1-4 alkyl, di -C 1-4 alkyl-C 1-4 alkyl-fluoro, cl gold, bromine, iodine and -CF3, heteroaryl, and heteroaryl substituted with one to three substituents independently selected from: C1-4 alkyl, di- (C1-4 alkyl) -amino- (C1-4 alkyl), fluoro, chloro, bromine, iodine and -CF3； R2 is selected from: aryl, aryl substituted with 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C1-4 alkyl, C1-4 alkyloxy, -OH, -COOH, -CONH2, -CF3, - ( C1-4 alkyl) -O- (C1-4 alkyl), -NO2, -NH2 and -CN, heteroaryl, heteroaryl substituted with 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C1-4 alkyl, C1-4 alkyloxy, -OH, -COOH, -CONH2, -CF3, - (C1-4 alkyl) -O- (C1-4 alkyl), -NO2, -NH2 and -CN, cycloalkyl, and cycloalkyl substituted with 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C1-4 alkyl, C1-4 alkyloxy, -OH, -COOH, -CONH2, -CF3, - (C1-4 alkyl) -O- (C1 alkyl -4), -NO2, -NH2 and -CN； and R3 is selected from: hydrogen, fluoro, chloro, bromo and iodo； or a salt thereof including a pharmaceutically acceptable salt thereof
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
