Thavalakulamgara K. Sasikumar,Duane A. Burnett,Theodros Asberom,Wen-Lian Wu,Hongmei Li,Ruo Xu,Hubert B. Josien
申请号：
US12668550
公开号：
US08618123B2
申请日:
2008.07.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are novel gamma secretase inhibitors of the formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, wherein L1, n, X, Ar, Y, Z, Q, and Q1 are as defined herein. Also disclosed are methods for inhibiting gamma secretase, methods for treating Alzheimers disease, methods of treating one or more neurodegenerative diseases, and methods of inhibiting the deposition of amyloid protein (e.g., amyloid beta protein) in, on or around neurological tissue (e.g., the brain) using the compounds of formula 1.0.
