GENTY PATRICK,젠티, 패트릭,HERMELIN CHRISTOPHE,헤르메린, 크리스토페,PEAN JEAN MANUEL,펜, 진-매뉴엘
申请号：
KR1020130011816
公开号：
KR1020130090365A
申请日:
2013.02.01
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A pharmaceutical composition for the long-term ejection of trimethazidine is provided to adjust the ejection of trimethazidine active ingredients with the function of time by the property and thickness of diluting agents at an external layer. CONSTITUTION: A pharmaceutical composition is a composition for the long-term ejection of trimethazidine. An inner phase of the pharmaceutical composition includes trimethazidine and an external layer of the pharmaceutical composition includes retarder and anti-agglomerant. The retarder is selected from ethyl cellulose, cellulose acetate, cellulose acetate butyrate, cellulose acetate propionate, cellulose acetate phthalate, hydroxypropyl methyl cellulose acetate succinate and/or polymethacrylate. [Reference numerals] (AA) Neutron core； (BB) Trimetazidine； (CC) Dihydrochloride； (DD) Outer layer； (EE) Ethyl cellulose； (FF) Talc； (GG) Acetyl tributyl citrate； (HH) Structure and formulation of pharmaceautical compositions； (II) Inner phase본 발명은 내부상이 트리메타지딘을 포함하고 외부층이 지연제 및 항-응집제를 포함하는 트리메타지딘의 장기간 방출을 위한 조성물에 관한 것이다.
