The object of the present invention is to provide the controlled excellence of transhipment in the lung of a kind of medicine or gene, be applicable to liposome through the lung administration.By surface with terminal hydrophobization polyvinyl alcohol and/or chitosan modified liposome, can suitably regulate and be enclosed intravital medicine of lipid or gene in the anelasticity on lung tissue surface and the animal migration in lung tissue, can control behavior in its organism.