PARK, Pil Joon,박필준,CHO, Si Young,조시영,LEE, Tae Ryong,이태룡,CHO, Eun-Gyung,조은경
申请号：
KRKR2017/006451
公开号：
WO2018/004173A1
申请日:
2017.06.20
申请国别(地区):
WO
年份:
2018
代理人:
摘要：
Disclosed in the specification are a composition comprising a suppressive material against SRBC expression or activity as an effective ingredient and a method for screening a suppressive material against adipocyte differentiation. A composition comprising a suppressive material against SRBC expression or activity as an effective ingredient according to an aspect of the present invention suppresses the differentiation of adipocytes and can be thus used for obesity prevention or alleviation. In addition, a method for screening a suppressive material against adipocyte differentiation according to an aspect of the present invention can screen a suppressive material against adipocyte differentiation simply, quickly, and effectively by treating dermal adipocytes with a test material and examining a relative expression level of an SRBC gene.Linvention concerne une composition comprenant comme principe actif une substance inhibant lexpression ou lactivité de SRBC, ainsi quune méthode de criblage de substances inhibitrices de la différenciation des adipocytes. Selon un aspect de la présente invention, une composition comprenant comme principe actif une substance inhibant lexpression ou lactivité de SRBC inhibe la différenciation des adipocytes et peut donc être utilisée pour prévenir ou atténuer lobésité. De plus, selon un aspect de la présente invention, une méthode de criblage de substances inhibitrices de la différenciation des adipocytes peut permettre de cribler des substances inhibitrices de la différenciation des adipocytes de façon simple, rapide et efficace en traitant les adipocytes du derme avec une substance à tester et en analysant le niveau relatif de lexpression du gène SRBC.본 명세서에는 SRBC 발현 또는 활성 억제 물질을 유효성분으로 포함하는 조성물 및 지방세포 분화 억제 물질의 스크리닝 방법이 개시된다. 본 발명의 일 측면인 SRBC의 발현 또는 활성 억제 물질을 유효성분으로 포함하는 조성물은 지방세포의 분화를 억제하여, 비만 예방 또는 개선용도로 사용될 수 있다. 또한, 본 발명의 일 측면인 지방세포 분화 억제 물질의 스크리닝 방법은, 피부 지방세포에 시험물질을 처리하고 SRBC 유전자의 상대적 발현 정도를 확인함으로써, 간편하고 신속하며 효율적으로 지방세포 분화 억제 물질을
