The present invention relates to a polypeptide construct comprising at least two fragments of an allergen from the Ambba family of allergens from Ambrosia artemisiifolia or a variant of said at least two fragments, wherein each of the at least two fragments has between 20 and 50 fragments. A polypeptide construct consisting of amino acid residues, wherein at least one fragment is derived from amino acid residues 1 to 50 of the mature allergen and at least one fragment is derived from amino acid residue 240 and ends at the C-terminus of the mature allergen . [Selection diagram] None本発明は、Ａｍｂｒｏｓｉａ ａｒｔｅｍｉｓｉｉｆｏｌｉａ由来のアレルゲンのＡｍｂ ａファミリー由来のアレルゲンの少なくとも２つの断片または前記少なくとも２つの断片のバリアントを含むポリペプチド構築物であって、少なくとも２つの断片の各々は２０から５０個のアミノ酸残基からなり、少なくとも１つの断片は成熟アレルゲンのアミノ酸残基１から５０に由来し、少なくとも１つの断片はアミノ酸残基２４０に由来し、成熟アレルゲンのＣ末端で終了する、ポリペプチド構築物に関する。【選択図】なし
