THÉRAPIES FONDÉES SUR LA RÉGULATION DE LA STABILITÉ ET DE LA FONCTION DES LYMPHOCYTES T RÉGULATEURS PAR L'INTERMÉDIAIRE D'UN AXE NEUROPILINE-1:SÉMAPHORINE
ST. JUDES CHILDRENS RESEARCH HOSPITAL;ST. JUDES CHILDREN'S RESEARCH HOSPITAL
发明人:
VIGNALI, DARIO, A. A.,WOO, SENG-RYONG,DELGOFFE, GREG, M.
申请号：
EP13846146
公开号：
EP2903692A4
申请日:
2013.10.08
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The invention is directed to treatment of cancer, infections and various inflammatory and autoimmune conditions by affecting regulatory T cell stability and function via a Neuropilin-1:Semaphorin axis. The present invention satisfies this and other needs by demonstrating that the regulatory T cell (Treg)-restricted neuropilin-1 (Nrp 1) interacts with the cell surface ligand semaphorin-4a (Sema4a) (e.g., on conventional T cells (Tconv), conventional dendritic cells (cDCs), and/or plasmacytoid dendritic cells (pDCs)) to potentiate reg function and enhance their survival at inflammatory sites.
