ST. JUDE CHILDREN'S RESEARCH HOSPITAL;ST. JUDE CHILDRENS RESEARCH HOSPITAL
发明人:
VIGNALI, DARIO A. A.,WOO, SENG-RYONG,DELGOFFE, GREG M.
申请号：
CA2886120
公开号：
CA2886120A1
申请日:
2013.10.08
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention is directed to treatment of cancer, infections and various inflammatory and autoimmune conditions by affecting regulatory T cell stability and function via a Neuropilin-1 :Semaphorin axis. The present invention satisfies this and other needs by demonstrating that the regulatory T cell (Treg)-restricted neuropilin-1 (Nrp 1) interacts with the cell surface ligand semaphorin-4a (Sema4a) (e.g., on conventional T cells (Tconv), conventional dendritic cells (cDCs), and/or plasmacytoid dendritic cells (pDCs)) to potentiate reg function and enhance their survival at inflammatory sites.
