JUNG, SUNG YOUB,HWANG, SANG YOUN,CHOI, IN YOUNG,PARK, SUNG HEE,KWON, SE CHANG
申请号：
CA2896934
公开号：
CA2896934A1
申请日:
2014.01.03
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention relates to an insulin secretion peptide derivative in which the charge on the N-terminus is modified and a pharmaceutical composition comprising the same, specifically, is characterized in that, in the insulin secretion peptide derivative, the positive charge on the N-terminus of an insulin secretion peptide is changed to a neutral charge or net negative charge in a neutral pH. The insulin secretion peptide derivative according to the present invention exhibits higher insulin secretion ability and blood glucose-reducing ability than natural insulin secretion peptides while maintaining the stability in the bloodstream because dissociation from a GLP-1 receptor rapidly progresses due to the change in the charge on the N-terminus, and thus is very useful in treating Type 2 diabetes.
