The present disclosure relates to methods and compositions for treating a active tuberculosis infection and methods and compositions for improving the efficacy of chemotherapy regimens against active tuberculosis infection. The present disclosure relates to methods of treating an active M. tuberculosis infection or an active infection resulting from reactivation of a latent infection in a mammal and to methods of improving the efficacy of chemotherapy regimens against active M. tuberculosis infection.La présente invention concerne des méthodes et des compositions pour le traitement d'une infection de tuberculose active. L'invention porte en outre sur des procédés et des compositions destinés à améliorer l'efficacité de régimes de chimiothérapie contre une infection de tuberculose active.