The present disclosure relates to methods and compositions for treating a active tuberculosis infection and methods and compositions for improving the efficacy of chemotherapy regimens against active tuberculosis infection. The present disclosure relates to methods of treating an active M. tuberculosis infection or an active infection resulting from reactivation of a latent infection in a mammal and to methods of improving the efficacy of chemotherapy regimens against active M. tuberculosis infection.La presente exposición se refiere a métodos y composiciones para tratar una infección activa por tuberculosis y a métodos y composiciones para mejorar la eficacia de los regímenes de quimioterapia contra la infección activa por tuberculosis.