Bruce D. HAMMOCK,Sung Hee HWANG,Ralph W. de VERE WHITE,Chong-xian PAN,Hongyong ZHANG,Paul HENDERSON,Ai-Hong MA,Maike ZIMMERMAN,Fuli WANG
申请号：
US16641430
公开号：
US20200197368A1
申请日:
2018.08.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided are methods and compositions for prolonging survival and/or reducing or inhibiting tumor growth in a cancer subject receiving a regimen of one or more chemotherapeutic agents, an inhibitor of soluble epoxide hydrolase (sEHi) and a non-steroidal anti-inflammatory drug (NSAID) that inhibits one or more enzymes selected from the group consisting of cyclo-oxygenase (“COX”)-1, COX-2, and 5-lipoxygenase (“5-LOX”). The methods and compositions decrease toxicity and/or adverse side effects in subjects receiving a regimen of one or more chemotherapeutic agents.
