SÉQUENCE NUCLÉOTIDIQUE OPTIMISÉE ET COMPOSITION PHARMACEUTIQUE SUR SA BASE AVEC UNE EXPRESSION PROLONGÉE DU TRANSGÈNE VEGF

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专利权人:

"Nextgen" Company Limited

发明人:

KISELEV, Sergey Lvovich

申请号：

EP15893474

公开号：

EP3305901A4

申请日:

2015.12.07

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Pointwise changes have been identified in the 3'UTR nucleotide sequence of the VEGF gene, which substantially increase the lifetime of its transcription product, i.e. mRNA in the cells of mammals. By experimentation, a gene construct has been selected with an optimal list of identified mutations, characterized by the longest lifetime of mRNA. The biological effect of the developed gene construct and the pharmaceutical composition based thereon has been confirmed in vitro and in vivo.

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