SEQUENCE NUCLEOTIDIQUE OPTIMISEE ET COMPOSITION PHARMACEUTIQUE SUR SA BASE AVEC UNE EXPRESSION PROLONGEE DU TRANSGENE VEGF

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专利权人:

COMPANY LIMITED "NEXTGEN"

发明人:

KISELEV, SERGEY LVOVICH

申请号：

CA2985608

公开号：

CA2985608A1

申请日:

2015.12.07

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Point changes to the 3'UTR nucleotide sequence of the VEGF gene which significantly increase the lifespan of the mRNA transcription product of said gene in mammalian cells have been identified. A gene construct with an optimal list of the identified mutations, which is characterized by a maximum mRNA lifespan, has been selected by experimentation. The biological effect of the gene construct developed and of a pharmaceutical composition based thereon have been confirmed in vitro and in vivo.

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中国工程科技知识中心

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