An anthranilic acid derivative represented by the general formula (X) [wherein Rrepresents hydrogen or a carboxy-protecting group； R representsoptionally substituted phenyl, a heterocyclic group, etc.； R representsoptionally substituted phenyl, a monocyclic heterocyclic group, etc.； Xrepresents carbonyl, etc.； X represents optionally substitutedalkylene, a bond, etc.； X represents oxygen, a bond, etc.； and Xrepresents a group represented by the general formula -X-X-or -X-X- (wherein X means oxygen, a bond, etc.；and X means optionally substituted alkylene, a bond, etc.)] or a saltof the derivative. The derivative or salt has an MMP-13 production inhibitoryactivity and is hence useful as a therapeutic agent for articular rheumatisum,osteoarthritis, cancer, etc.
