Compound that is: a) of formula: ** Formula ** or b) of formula: ** Formula ** or c) of formula: ** Formula ** or ** Formula ** in which, R3 is trifluoromethyl； or d) of formula: ** Formula ** in which R3 is hydrogen or e) of formula: ** Formula ** in which: each of Z1, Z2, Z3 and Z4 is independently N or CR6； each R6 is independently hydrogen, cyano, halogen, OR7, NR8R9, amino, hydroxyl or alkyl, alkylaryl or optionally substituted alkyl heterocycle； each R7 is independently hydrogen or optionally substituted alkyl, alkyl-aryl or alkyl-heterocycle； each R8 is independently hydrogen or optionally substituted alkyl, aryl or alkyl heterocycle； each R9 is independently hydrogen or optionally substituted alkyl, aryl or alkyl heterocycle； and m is 1-4, or f) of the formula: ** Formula ** in which: each of Z'1, Z'2 and Z'3 is independently N, NH, S, O or CR6； each R6 is independently amino, cyano, halogen, hydrogen, OR7, SR7, NR8R9 or optionally substituted alkyl, alkyl-aryl or alkyl heterocycle； each R7 is independently hydrogen or optionally substituted alkyl, alkyl-aryl or alkyl-heterocycle； each R8 is independently hydrogen or optionally substituted alkyl, aryl or alkyl heterocycle； each R9 is independently hydrogen or optionally substituted alkyl, aryl or alkyl heterocycle； and p is 1-3 or a pharmaceutically acceptable salt or solvate salt thereof, in which in the formula a), b), c), d), e) of): A, A1 and / or A2 is optionally substituted cycloalkyl, aryl or heterocycle； D is pyrimidine； E is optionally substituted aryl or heterocycle； X is -O-, -S-, -C (O) -, -C (R4)>； =,>； = C (R4) -, -C (R3R4) -, -C (R4)>； = C (R4 ) -, -C≡C-, -N (R5) -, -N (R5) C (O) N (R5) -, -C (R3R4) N (R5) -, -N (R5) C (R3R4 ) -, -ONC (R3) -, -C (R3) NO-, -C (R3R4) O-, -OC (R3R4) -, -S (O2) -, -S (O2) N (R5) - , -N (R5) S (O2) -, -C (R3R4) S (O2) - or -S (O2) C (R3R4) -； R1 is hydrogen or optionally substituted alkyl, alkyl-aryl, alkyl-heterocycle, aryl or heterocycle； R2 is hydrogen or
