INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIPO I PCT omit VIII °nolo Him olo Ho mo 10 1111111 ow (10) International Publication Number WO 2018/193477 Al W O 20 18/ 193 477 Al (51) International Patent Classification: A61K 35/76 (2015.01) (21) International Application Number: PCT/IN2018/050238 (22) International Filing Date: 20 April 2018 (20.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201711014310 21 April 2017 (21.04.2017) IN (71) Applicant: INDIAN INSTITUTE OF TECHNOLOGY, DELHI [IN/IN]； Indian Institute of Technology Delhi Hauz Khas, New Delhi, Delhi 110 016 (IN). (72) Inventors: HASNAIN, Seyed Ehtesham； Kusuma School of Biological Sciences Indian Institute of Technology Del- hi Hauz Khas, New Delhi 110 016 (IN). EHTESHAM, Nasreen Zafar； National Institute of Pathology Safdarjang Hospital Campus, Ansari Nagar West, New Delhi 110029 (IN). TRIPATHI, Deeksha； Kusuma School of Biological Sciences Indian Institute of Technology Delhi Hauz Khas, New Delhi 110 016 (IN). GROVER, Sonam； Kusuma School of Biological Sciences Indian Institute of Technolo- gy Delhi Hauz Khas, New Delhi 110 016 (IN). KUMAR, Ashutosh； Kusuma School of Biological Sciences Indian Institute of Technology Delhi Hauz Khas, New Delhi 110 016 (IN). ALAM, Anwar； Kusuma School of Biological Sciences Indian Institute of Technology Delhi Hauz Khas, New Delhi 110 016 (IN). PANDEY, Saurabh； Kusuma School of Biological Sciences Indian Institute of Technolo- gy Delhi Hauz Khas, New Delhi 110 016 (IN). (74) Agent: LAKSHMIKUMARAN, Malathi et al.； B6/10, Safdarjung Enclave, New Delhi 110029 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE,
