BECK, ELIZABETH MARY,BRODNEY, MICHAEL AARON,BROWN, MATTHEW FRANK,BUTLER, CHRISTOPHER RYAN,GILBERT, ADAM MATTHEW,LACHAPELLE, ERIK ALPHIE,MCALLISTER, LAURA ANN,UCCELLO, DANIEL PAUL,ZHANG, LEI
申请号:
CA3066986
公开号:
CA3066986A1
申请日:
2018.06.14
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The present invention provides, in part, compounds of Formula I, or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N- oxide, wherein: (R1)a, (R2)b, (R3)c, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4- associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.