Conformationally stable analogs of the response selective C5a agonist EP67

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专利权人:

Board of Regents of the University of Nebraska

发明人:

Sanderson, Sam D.,Vennerstrom, Jonathan

申请号：

AU2016228771

公开号：

AU2016228771A1

申请日:

2016.03.11

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Conformationally-stable peptide analogs of the response selective C5a agonist EP67 having the formula Tyr-Ser-Phe-Lys-Asp-Met-Xaa-(Xaa2)-(D-Ala)-Arg (SEQ ID NO:1), wherein Xaa is a modified proline residue or a residue substitution for proline, and Xaa2 is leucine or N-methyl leucine. The conformationally-stable peptides selectively bind and activate APCs without directly engaging/binding C5a receptor-bearing cells involved in pro-inflammatory activities of natural C5a. Compositions and methods of using the peptide analogs are also described.

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