CONFORMATIONALLY STABLE ANALOGS OF THE RESPONSE SELECTIVE C5A AGONIST EP67

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专利权人:

发明人:

SANDERSON SAM D,VENNERSTROM JONATHAN

申请号：

IN201727035061

公开号：

IN201727035061A

申请日:

2017.10.03

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

Conformationally stable peptide analogs of the response selective C5a agonist EP67 having the formula Tyr Ser Phe Lys Asp Met Xaa (Xaa2) (D Ala) Arg (SEQ ID NO:1) wherein Xaa is a modified proline residue or a residue substitution for proline and Xaa2 is leucine or N methyl leucine. The conformationally stable peptides selectively bind and activate APCs without directly engaging/binding C5a receptor bearing cells involved in pro inflammatory activities of natural C5a. Compositions and methods of using the peptide analogs are also described.

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