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CONFORMATIONALLY STABLE ANALOGS OF THE RESPONSE SELECTIVE C5A AGONIST EP67
专利权人:
发明人:
SANDERSON SAM D,VENNERSTROM JONATHAN
申请号:
IN201727035061
公开号:
IN201727035061A
申请日:
2017.10.03
申请国别(地区):
IN
年份:
2017
代理人:
摘要:
Conformationally stable peptide analogs of the response selective C5a agonist EP67 having the formula Tyr Ser Phe Lys Asp Met Xaa (Xaa2) (D Ala) Arg (SEQ ID NO:1) wherein Xaa is a modified proline residue or a residue substitution for proline and Xaa2 is leucine or N methyl leucine. The conformationally stable peptides selectively bind and activate APCs without directly engaging/binding C5a receptor bearing cells involved in pro inflammatory activities of natural C5a. Compositions and methods of using the peptide analogs are also described.
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