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FUNCTIONAL ANTIBODY FRAGMENT COMPLEMENTATION FOR A TWO-COMPONENTS SYSTEM FOR REDIRECTED KILLING OF UNWANTED CELLS
专利权人:
REVITOPE LIMITED
发明人:
COBBOLD, MARK
申请号:
CA3003482
公开号:
CA3003482A1
申请日:
2016.11.18
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
A targeted T-cell engaging agent for treating a condition characterized by the presence of unwanted cells includes (a) a targeting moiety that is capable of targeting the unwanted cells (b) a first T-cell engaging domain capable of T-cell engaging activity when binding a second T-cell engaging domain, wherein the second T-cell engaging domain is not part of the agent (c) at least one inert binding partner capable of binding to the first T-cell engaging domain such that the first T-cell engaging domain does not bind to the second T-cell engaging domain unless the inert binding partner is removed and (d) at least one cleavage site separating the first T-cell engaging domain and the inert binding partner, wherein the cleavage site is: (i) cleaved by an enzyme expressed by the unwanted cells (ii) cleaved through a pHsensitive cleavage reaction inside the unwanted cell (iii) cleaved by a complementdependent cleavage reaction.
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中国工程科技知识中心
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