COMBINAISON D'UN ANTICORPS ANTI-CD20, D'UN INHIBITEUR SÉLECTIF DE P13 KINASE-DELTA ET D'UN INHIBITEUR DE BTK POUR TRAITER DES TROUBLES PROLIFÉRATIFS DES LYMPHOCYTES B
TG Therapeutics Inc.;Rhizen Pharmaceuticals S.A.;Laboratoire Français du Fractionnement et des Biotechnologies
发明人:
WEISS, Michael, S.,MISKIN, Hari, P.,SPORTELLI, Peter
申请号：
EP17803731
公开号：
EP3463318A4
申请日:
2017.05.26
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Methods for inhibiting proliferation of a B-cell population are provided comprising administering a combination of agents, comprising: (i) at least one P13K-delta selective inhibitor； (ii) at least one anti-CD20 antibody； and (iii) at least one Bruton's tyrosine kinase (BTK) inhibitor. Methods for treating B-cell proliferative disorders, such as B-cell hematological malignancies, as well as kits for carrying out the claimed methods, are also provided.
