COMBINAISON D'UN ANTICORPS ANTI-CD20, D'UN INHIBITEUR SELECTIF DE P13 KINASE-DELTA ET D'UN INHIBITEUR DE BTK POUR TRAITER DES TROUBLES PROLIFERATIFS DES LYMPHOCYTES B
TG THERAPEUTICS; INC.;RHIZEN PHARMACEUTICALS S.A.;TG THERAPEUTICS, INC.;LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES
发明人:
WEISS, MICHAEL S.,MISKIN, HARI P.,SPORTELLI, PETER
申请号：
CA3024123
公开号：
CA3024123A1
申请日:
2017.05.26
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Methods for inhibiting proliferation of a B-cell population are provided comprising administering a combination of agents, comprising: (i) at least one P13K-delta selective inhibitor； (ii) at least one anti-CD20 antibody； and (iii) at least one Bruton's tyrosine kinase (BTK) inhibitor. Methods for treating B-cell proliferative disorders, such as B-cell hematological malignancies, as well as kits for carrying out the claimed methods, are also provided.
