DE KRUIF, CORNELIS ADRIAAN,HENDRIKS, LINDA JOHANNA ALEIDA,LOGTENBERG, TON,VAN LOO, PIETER FOKKO
申请号：
CA3094318
公开号：
CA3094318A1
申请日:
2019.03.29
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains； and at least one additional binding domain, wherein the base antibody portion is connected by a linker to the at least one additional binding domain, wherein each binding domain of the base antibody portion and each of the at least one additional binding domains all have a common variable region, and wherein the linker comprises a hinge sequence or a sequence derived from a hinge sequence. The invention also relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains； and at least one additional binding domain, wherein at least one additional binding domain comprises a CH1 region and is connected to the base antibody portion by said linker, linking a variable region of the base antibody portion and the CH1 region, and wherein the multivalent antibody binds to at least three different epitopes.
