DE KRUIF, Cornelis Adriaan,HENDRIKS, Linda Johanna Aleida,LOGTENBERG, Ton,VAN LOO, Pieter Fokko
申请号：
AU2019243665
公开号：
AU2019243665A1
申请日:
2019.03.29
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The invention relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains； and at least one additional binding domain, wherein the base antibody portion is connected by a linker to the at least one additional binding domain, wherein each binding domain of the base antibody portion and each of the at least one additional binding domains all have a common variable region, and wherein the linker comprises a hinge sequence or a sequence derived from a hinge sequence. The invention also relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains； and at least one additional binding domain, wherein at least one additional binding domain comprises a CH1 region and is connected to the base antibody portion by said linker, linking a variable region of the base antibody portion and the CH1 region, and wherein the multivalent antibody binds to at least three different epitopes.
